I think there is little difference between R/Me and Me/R as far as defense is concerned, however being Me/R tends to get you killed faster because for various reasons (warriors especially) like to go after mesmers. You will have a bit more energy to work with and faster energy regen I believe as a Me/R but you lose out on some defense. I think they're almost equally good. Like one of the previous posters said, interrupting certain classes is quite tricky because of rather quick cast times such as many healing skills of a monk.
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